In battle
When a Pokémon with this Ability is hit by a move that makes contact, there is a 10% chance that the attacking Pokémon will become either poisoned, paralyzed, or asleep, with a 3.3% probability each.

If a Pokémon with this Ability is hit by a multi-strike move that makes contact (such as Fury Swipes), each hit has an independent chance to activate this Ability.

If a Pokémon is immune to some of the status conditions, then the chance of inflicting each of the remaining conditions is constant, so the total chance of successfully inflicting a condition decreases.

Outside of battle
Effect Spore has no effect outside of battle.

In battle
If the Pokémon is poisoned or badly poisoned, it will gain 1/8 of its maximum HP at the end of each turn instead of taking damage.

When a Pokémon with Poison Heal is badly poisoned, this has no effect on the Pokémon's HP recovery. However, the bad poison counter still increases each turn even if the Pokémon has Poison Heal; as such, if Gastro Acid is used on the Pokémon with Poison Heal after being badly poisoned for five turns, it will incur poison damage starting at 5/16 (instead of 1/16).

If a poisoned Pokémon with Poison Heal is affected by Heal Block, it will be neither healed nor damaged by the poison.

Outside of battle
Poison Heal has no effect outside of battle, so in Generation IV, poison will still hurt a Pokémon outside of battle even if it has this Ability.